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FRAGMENT LIBRARY

3k Proteros hand-selected fragments

  • Ro3 compliant, MW 160- 300 g/mol, solubility checked
  • High diversity, max Tanimoto similarity of 0.66
  • High concentration collection (100 mM DMSO stock concentration -> up to 1 mM screening concentration)
  • Application: Fragment screening

RANGE FINDER LIBRARY

Fragment-enriched 41k small molecules library

  • Fragment enriched (25% MW < 300 g/mol
  • Sorted by size: 10,000 Fragments can be screened separately
  • High sp3 fraction, average sp3 fraction = 0.42
  • Applications: Combination of fragment and small molecule screen
  • Screen of smaller library with high hit rates

SMALL MOLECULE LIBRARY

150k high quality small molecules

  • High diversity
  • Specific clustering concept (23,598 clusters, mean cluster size = 6)
  • Additional cluster members available by expansion into full range of Enamine compounds
  • Application: HTS

RANGE FINDER + SMALL MOLECULE LIBRARY

191k high quality small molecules (fragment enriched)

  • Combination of range finder and small molecule diversity library
  • Application: HTS

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assays, biophysics and screening experts led by 7 PhDs with access to cutting-edge laboratories

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protein specialists representing a strong academic pedigree with substantial peer-reviewed publications

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PhDs with structural biology and drug discovery background