Libraries for HT and fragment screening

PAINS-free screening libraries [no pan-assay interference compounds] designed by deselection of reactive compounds and unfavorable physicochemical properties
All libraries Ro3 or Ro5 compliant
Proteros hand-selected compounds/fragments from Enamine
Hit expansion into full-range of available Enamine compounds
Fast synthesis of hit analogues at Enamine (building blocks available)
Easy and cost-efficient access to high quality screening libraries
Rapid transition into Proteros structural biology platform

Fast HTS follow up using:
- Reporter Displacement Assay (RDA)
- Enzymatic Assays
- TSA
- SPR
- MST
- nanoDSF
- nanoBRET

FIND A gallery assay

Proteins, Structures and Assays

Select an option:

Variant Catalog No SwissProtID

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FRAGMENT LIBRARY

3k Proteros hand-selected fragments

Ro3 compliant, MW 160- 300 g/mol, solubility checked
High diversity, max Tanimoto similarity of 0.66
High concentration collection (100 mM DMSO stock concentration -> up to 1 mM screening concentration)
Application: Fragment screening

RANGE FINDER LIBRARY

Fragment enriched 41k small molecules library

Fragment enriched (25% MW < 300 g/mol
Sorted by size: 10,000 Fragments can be screened separately
High sp3 fraction, average sp3 fraction = 0.42
Applications: Combination of fragment and small molecule screen
Screen of smaller library with high hit rates

SMALL MOLECULE LIBRARY

150k high quality small molecules

High diversity
Specific clustering concept (23,598 clusters, mean cluster size = 6)
Additional cluster members available by expansion into full range of Enamine compounds
Application: HTS

RANGE FINDER + SMALL MOLECULE LIBRARY

191k high quality small molecules (fragment enriched)

Combination of range finder and small molecule diversity library
Application: HTS

Why use the Proteros Screening services