CRYO-EM
Premium, industrialized cryo-EM Facility. The cryo-EM process at Proteros has been developed and honed to reliably generate structural data. From our in-house experts in protein preparation and cryo-EM, to our range of microscopes we have the experience and technology to deliver world-class results to help you REACH RIGHT FASTER.
Protein Science
Expression, Purification and Analytics
Top-tier protein science platform to deliver the RIGHT proteins and complexes
Grid Preparation & Negative Staining
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Grid preparation (Vitrobot Mark IV)
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Tecnai Spirit & Phillips CM100 microscopes access for negative staining EM screening and data collection
High-end cryo-EM microscopes
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Glacios cryo-EM microscope with cutting-edge Falcon 4 direct electron detector for cryo-EM grid screening, low- and high-resolution data collection (≥ 3 Å resolution); also access to Titan Krios (2-3 Å)
X-RAY CRYSTALLOGRAPHY
Premium, industrialized X-Ray Crystallography facility. We look back upon 20 successful years of serving the pharma and biotech drug discovery community with meaningful structures. We have optimized every single step from protein construct design down to high-resolution structure for you. We use automation combined with deep industry expertise to provide a reliable process for generating high-resolution crystallography data to help you REACH RIGHT FASTER.
PROTEIN SCIENCE
Expression, Purification and Analytics
Top-tier protein science platform to deliver the RIGHT protein sample
Industrialized crystallization platform
Robotics for efficient and reliable drop setting
up to 2000 initial crystallization conditions
Automated imaging to monitor crystallization events
Free Mounting System
Optimizes protein crystal diffraction characteristics.
Additional FMS modules:
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- FMS-Laser applies defined heat cycles
- FMS-Aerosol Generator applies organic solvents or ligands
- FMS-cryo Switch gently freezes crystals
DATA Collection
- Co-ownership of a synchrotron beamline Swiss Light Source, SLS (Paul Scherrer Institute, Switzerland; Photo source/credit: Paul Scherrer Institute)
- Premium Eiger2 X 16M detector and automatic sample changer TELL
- On-site and remote access
Structural Elucidation
- Proprietary automated pipeline for data processing and structure solution (MIR/MAD/SAD and Molecular Replacement)
- STARANISO (Global Phasing Ltd) to enable challenging anisotropic data processing
- Integrated with Cambridge Structural Database (CSD)